May 23, · Although anyone can develop acne, cystic acne tends to occur in people with oily skin. It’s also more common in teens, women, and older adults with hormonal imbalances. Usually, cystic acne can Author: Kristeen Cherney. Apr 22, · Because cystic acne is rooted deep within the skin tissue, with no direct connection to the surface. So all the spot treatments and cleansers in the world can’t penetrate far enough to treat the Occupation: Deputy Beauty Director.